Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/274999923?client_source=feed&format=rss
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Monday, January 7, 2013
Genetic mystery of Behcet's disease unfolds along the ancient Silk Road
Jan. 6, 2013 ? Researchers have identified four new regions on the human genome associated with Behcet's disease, a painful and potentially dangerous condition found predominantly in people with ancestors along the Silk Road. For nearly 2,000 years, traders used this 4,000-mile network linking the Far East with Europe to exchange goods, culture and, in the case of the Silk Road disease, genes. National Institutes of Health researchers and their Turkish and Japanese collaborators published their findings in the Jan. 6, 2013, advance online issue of Nature Genetics.
Named for the Turkish physician who described it in 1937, Behcet's (pronounced BET'-chets) disease is triggered by complex genetic and environmental factors, and causes inflammation of blood vessels in various parts of the body. Common symptoms include painful mouth and genital sores, and eye inflammation that can lead to blindness. In some cases, it can be life-threatening, affecting blood vessels in the brain, lungs, and other vital organs. About 1 in 250 people in Turkey have Behcet's disease; others with the disease are found largely in regions along the Silk Road.
Genetic factors are thought to play a role in susceptibility to Behcet's disease, with the human leukocyte antigen (HLA) B-51 gene region of the genome, accounting for about 20 percent of genetic risk for the disease. Researchers have been aware of the HLA B-51 association for about 40 years. Two years ago, the research team identified gene associations at two other specific chromosome locations, or loci.
"The current study represents an important advance because it dramatically broadens the spectrum of genetic loci associated with Behcet's disease," said Dan Kastner, M.D., Ph.D., scientific director of the Intramural Research Program at the National Human Genome Research Institute and senior author of the study. "These newly discovered genetic associations provide a link between Behcet's disease and other more common illnesses, and thereby suggest new therapies for Behcet's disease. In addition, two of the newly discovered genes provide an intriguing link between genes and the microbes in our environment."
Researchers conducted a genome-wide association study (GWAS) that enrolled 1,209 Turkish people affected by Behcet's disease and 1,278 unaffected Turkish people -- all residents of the country. They looked at many points on the human genome called single-nucleotide polymorphisms (SNPs), with each SNP representing a difference in a single DNA building block, called a nucleotide. Researchers then compared SNP differences between people with and without disease.
From nearly 800,000 SNPs, researchers detected and mapped a small number that are found in those who have Behcet's disease at a significantly higher rate than in those without the disease, suggesting that the variant or another one nearby contributes to the disease.
"Each of the genetic factors may contribute a little to the overall risk of disease," said Elaine F. Remmers, Ph.D., staff scientist in NHGRI's Inflammatory Disease Section and study co-author. "We are also identifying them in pathways that are important in inflammatory disease development."
She noted that not all of the 800,000 gene variants analyzed were directly genotyped. Genotyping involves examining a person's DNA at a site where a variation is commonly known to occur. Instead, the team used the strategy of imputing, or surmising, that there were genotypes worth investigating near known variants.
"That worked very well for us," Dr. Remmers said. "We found that our predicted genotypes were pretty good and that the associations we found were quite similar in both the predicted and the experimentally confirmed genotypes."
Each of the four newly identified gene regions is already known to play a role in immune regulation. The genetic associations have helped classify Behcet's disease with more common inflammatory conditions such as psoriasis, inflammatory bowel disease and a form of spinal arthritis called ankylosing spondylitis.
Among the newly identified regions, researchers found:
- An important association between Behcet's disease and a gene called ERAP1. ERAP1 codes for a molecule that processes microbial proteins in white blood cells. Variants of this protein can lead to more or less efficient processing of microbial proteins before they are loaded onto HLA molecules for presentation to the immune system. The variants of ERAP1 identified in this study increase the risk of Behcet's disease, but only in those individuals with one specific HLA type, HLA-B51, which has previously been associated with Behcet's disease. Dr. Kastner speculates that the ERAP1 variant associated with Behcet's disease processes microbial proteins in such a way that they can be loaded onto the HLA-B51 molecule to trigger an abnormal immune response. The very same variant of ERAP1 that is associated with Behcet's disease is protective for ankylosing spondylitis and psoriasis, but only in people with the HLA types associated with those diseases.
- A significant association of Behcet's disease with variants near the CCR1 gene. Proteins coded by this gene help infection-fighting blood cells migrate to sites of invading microorganisms. When this function is defective, the microorganisms can trigger a persistent inflammatory response.
- An association of the disease with variants in the KLRC4 gene. The function of the receptor protein coded by this gene is not well understood, but the researchers suggest that it may be important to investigate further because it is located within the genomic region with the strongest evidence for linkage to a disease gene in a study of Turkish family health histories in which members sometimes have a rare familial form of Behcet's disease.
- An association with the STAT4 gene, in which different variants in the same vicinity of the genome increase risk for autoimmune diseases, including rheumatoid arthritis and lupus.
"We are incredibly excited about these latest findings," Dr. Kastner said. "Combined with our studies two years ago, the current genetic data make a strong case for a causal connection between Behcet's disease and disorders such as ankylosing spondylitis, psoriasis, and inflammatory bowel disease. This raises real hope that some of the treatments that have been found effective in these other illnesses will have some utility in Behcet's disease, thereby helping to alleviate suffering and prevent mortality."
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The above story is reprinted from materials provided by NIH/National Human Genome Research Institute, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Yohei Kirino, George Bertsias, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Ozyazgan, F Sevgi Sacli, Burak Erer, Hidetoshi Inoko, Zeliha Emrence, Atilla Cakar, Neslihan Abaci, Duran Ustek, Colleen Satorius, Atsuhisa Ueda, Mitsuhiro Takeno, Yoonhee Kim, Geryl M Wood, Michael J Ombrello, Akira Meguro, Ahmet G?l, Elaine F Remmers, Daniel L Kastner. Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1. Nature Genetics, 2013; DOI: 10.1038/ng.2520
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/x3dJXxcJZko/130106145739.htm
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Sunday, January 6, 2013
Hurricane Sandy Aid Bill Passes House
Long Island Residents, Many Still Without Power, Continue To Clean Up After Superstorm Sandy
LONG BEACH, NY - NOVEMBER 09: A man walks past a destroyed section of the boardwalk at the base of Lincoln Boulevard as Long Islanders continue their clean up efforts in the aftermath of Superstorm Sandy on November 9, 2012 in Long Beach, New York. New York Gov. Andrew M. Cuomo has said that the economic loss and damage to homes and business caused by Sandy could total $33 billion in New York, according to published reports. (Photo by Bruce Bennett/Getty Images)
Storm-Damaged Communities On East Coast Hit By Nor'Easter
NEW YORK, NY - NOVEMBER 08: Alex Vila, 2, carries a box of cereal after visiting an aid station for people affected by Superstorm Sandy on November 8, 2012 in the Brooklyn borough of New York City. Household supplies and groceries were distributed to Red Hook neighborhood residents by Catholic Charities at the Visitation of the Blessed Virgin Mary church. Meanwhile a nor'easter storm plunged temperatures to below freezing, bringing more misery to many Red Hook residents still without power, heat nor running water in their public housing apartments. (Photo by John Moore/Getty Images)
US-WEATHER-STORM-SANDY
Boats and docks damaged by Hurricane Sandy are seen at the Mansion Marinia on the shores of the Great Kills community November 7, 2012 on Staten Island, New York. New York Mayor Michael Bloomberg on Tuesday announced a limited evacuation of some neighborhoods ahead of harsh weather barreling toward a city still recovering from superstorm Sandy. The national weather service forecast heavy rain and likely snow on Wednesday and Thursday, accompanied by gale force winds gusting as high as 43 mph (69 kmh). Though barely half the strength of Sandy, the autumn storm will lash already damaged buildings and bring lower temperatures for tens of thousands of people still struggling without electricity. Bloomberg told a news conference that parks and beaches would close. The worst-hit patches of waterfront neighborhoods, including Rockaways in the Queens borough, and in Staten Island, were being asked to evacuate again. AFP PHOTO/Paul J. Richards (Photo credit should read PAUL J. RICHARDS/AFP/Getty Images)
Storm-Damaged Communities On East Coast Hit By Nor'Easter
LONG BRANCH, NJ - NOVEMBER 08: Debris from Superstorm Sandy is seen on a beach November 8, 2012 in Long Branch, New Jersey. Meanwhile a nor'easter storm plunged temperatures to below freezing, bringing more misery to many residents throughout New York and New Jersey still without power. (Photo by Allison Joyce/Getty Images)
Long Island Residents, Many Still Without Power, Continue To Clean Up After Superstorm Sandy
OCEANSIDE, NY - NOVEMBER 09: (L-R) James Vouloukos and William Ferris sort through donated clothes at a site maintained by the Town of Hempstead in cooperation with FEMA at Oceanside Park during in the aftermath of Superstorm Sandy on November 9, 2012 in Oceanside, New York. New York Gov. Andrew M. Cuomo has said that the economic loss and damage to homes and businesses caused by Sandy could total $33 billion in New York, according to published reports. (Photo by Bruce Bennett/Getty Images)
Funeral Held in Brooklyn For Two Young Brothers Killed During Superstorm Sandy
NEW YORK, NY - NOVEMBER 09: New York sanitation department workers watch as a hearse arrives with a casket carrying the bodies of two brothers killed during Superstorm Sandy for a funeral at the St. Rose of Lima Catholic church on November 9, 2012 in the Brooklyn borough of New York City. Brandon Moore, 2, and Connor Moore, 4, were swept away from the arms of their mother Glenda Moore as she fled Superstorm Sandy floodwaters in New York's Staten Island borough to seek safety with family in Brooklyn. She is married to New York Sanitation worker Damian Moore, and dozens of workers and officials from the sanitation department attended the funeral ceremony. (Photo by John Moore/Getty Images)
Long Island Residents, Many Still Without Power, Continue To Clean Up After Superstorm Sandy
ISLAND PARK, NY - NOVEMBER 09: (L-R) Residents Paul and Donald Zezulinski and their dog 'Plywood' of Island Park show their appreciation to first responders during their clean up efforts in the aftermath of Superstorm Sandy on November 9, 2012 in Island Park, New York. New York Gov. Andrew M. Cuomo has said that the economic loss and damage to homes and business caused by Sandy could total $33 billion in New York, according to published reports. (Photo by Bruce Bennett/Getty Images)
FILE - In this Tuesday, Oct. 30, 2012 file photo, people stand next to a house collapsed from Superstorm Sandy in East Haven, Conn. While Connecticut was spared the destruction seen in New York and New Jersey, many communities along the shoreline, including some of the wealthiest towns in America, were struggling with one of the most severe storms in generations. (AP Photo/Jessica Hill, File)
Meg Dolan holds her dog "Nellie" during Sunday mass at St. Thomas More Catholic Church in Breezy Point, in the wake of Superstorm Sandy, Sunday, Nov. 4, 2012, in New York. With overnight temperatures sinking into the 30s and hundreds of thousands of homes and businesses still without electricity six days after Sandy howled through, people piled on layers of clothes, and New York City officials handed out blankets and urged victims to go to overnight shelters or daytime warming centers. (AP Photo/Kathy Willens)
A representative of the Salvation Army walks past homes destroyed by Superstorm Sandy in Breezy Point, Sunday, Nov. 4, 2012, in New York. The beachfront neighborhood heavy populated by firefighters and police officers was devastated during the storm when a fire pushed by Sandy's raging winds destroyed 100 or more homes and buildings. (AP Photo/Kathy Willens)
Ginny Flanagan, right, and her sister go through photographs and mementos that were recovered from Flanagan's flooded bungalow in Breezy Point, in the wake of Superstorm Sandy, Sunday, Nov. 4, 2012, in New York. The beachfront enclave heavy populated by firefighters and police officers was devastated during the storm when a fire pushed by Sandy's raging winds destroyed 100 or more homes and buildings. (AP Photo/Kathy Willens)
US-WEATHER-STORM-SANDY-MARATHON
Runner Jonathan who would have run the ING New York City Marathon, spend the afternoon volunteering by unloading and organizing emergency supplies near Midland Beach as New York recovers from Hurricane Sandy on November 4, 2012 in Staten Island, New York. AFP PHOTO / Mehdi Taamallah (Photo credit should read MEHDI TAAMALLAH/AFP/Getty Images)
A woman with her groceries passes a group of National Guardsmen as they march up 1st Avenue towards the 69th Regiment Armory, Saturday, Nov. 3, 2012, in New York. National Guardsmen remain in Manhattan as the city begins to move towards normalcy following Superstorm Sandy earlier in the week. (AP Photo/ John Minchillo)
Patrons on foot carrying gas canisters line up for gasoline at a Hess station in the New Dorp section of the Staten Island borough of New York, Saturday, Nov. 3, 2012. Those on foot reported waits up to 40 minutes while motorists lined up for two hours as Staten Islanders fueled up to run their generators and automobiles in the wake of Superstorm Sandy. (AP Photo/Eileen AJ Connelly)
Girls hold hands during Sunday mass at St. Thomas More Catholic Church in Breezy Point, in the wake of Superstorm Sandy, Sunday, Nov. 4, 2012, in New York. With overnight temperatures sinking into the 30s and hundreds of thousands of homes and businesses still without electricity six days after Sandy howled through, people piled on layers of clothes, and New York City officials handed out blankets and urged victims to go to overnight shelters or daytime warming centers. (AP Photo/Kathy Willens)
Many streets in the Silver Lake section of Belmar, N.J., remain underwater Saturday, Nov. 3, 2012, Neighbors and volunteers clean out homes Saturday, Nov. 3, 2012, in Belmar, N.J., five days after the storm surge by superstorm Sandy. (AP Photo/Ben Nukols)
Water from superstorm Sandy is pumped from a flooded basement of an office building near New York's Battery Park, Friday, Nov. 2, 2012. The massive storm that started out as Hurricane Sandy slammed into the East Coast and morphed into a huge and problematic system, killing at least 96 people in the United States. The cost of the storm could exceed $18 billion in New York alone. (AP Photo/Richard Drew)
Cars that were uprighted and submerged by Superstorm Sandy remain at the entrance of a subterranean parking garage in New York's Financial District, as the water is pumped out, Friday, Nov. 2, 2012. . The cost of the storm could exceed $18 billion in New York alone. (AP Photo/Richard Drew)
National Guard in Lower Manhattan
The National Guard 827th Engineer Company helps hand out MREs to Lower Manhattan residents at the Alfred Smith Playground on Friday Nov. 2, 2012. (Damon Dahlen, AOL)
National Guard in Lower Manhattan
The National Guard 827th Engineer Company helps hand out MREs to Lower Manhattan residents at the Alfred Smith Playground on Friday Nov. 2, 2012. (Damon Dahlen, AOL)
Grand Central Terminal, New York City
People walk through Grand Central Terminal as the sun rises during a subdued morning rush on Nov. 1, 2012 in New York City. Some trains are back up and running into Grand Central following shutdowns in the aftermath of Superstorm Sandy. Subway train service in the city is back in a limited capacity, but with much of lower Manhattan still with out power, trains are not running there and busses are replacing them.
Seaside Heights, N.J.
A roller coaster sits in the Atlantic Ocean after the Fun Town pier it sat on was destroyed by Superstorm Sandy on Nov. 1, 2012 in Seaside Heights, New Jersey. With the death toll continuing to rise and millions of homes and businesses without power, the U.S. east coast is attempting to recover from the effects of floods, fires and power outages brought on by Superstorm Sandy.
National Guard in Lower Manhattan
The National Guard 827th Engineer Company helps hand out MREs to Lower Manhattan residents at the Alfred Smith Playground on Friday Nov. 2, 2012. (Damon Dahlen, AOL)
Charging Station Provided By AT&T
Phillip Melly charges the phones of Hurricane Sandy victims at Kimlau Square in Lower Manhattan on Friday Nov. 2, 2012. The generators used were brought in by AT&T to help out the residents of Lower Manhattan in New York City who currently have no power. (Damon Dahlen, AOL)
Stocking Up On Ice
United City Ice Cube Company workers who refer to themselves as "Icemen" take in a shipment of ice into their 45th and 10th ave. store on Friday Nov. 2, 2012. The workers who asked not to be identified by name said there had been a run on ice purchases due to Hurricane Sandy and they were stocking up in anticipation of more demand in the coming days. (Damon Dahlen, AOL)
Car Crash Due To Power Outage
The power outage in Lower Manhattan due to Hurricane Sandy has created a gauntlet of dangerous street intersections as can be seen by this car accident at the Houston and Varick Street crossing on Friday Nov. 2, 2012. (Damon Dahlen, AOL)
Car Crash Due To Power Outage
The power outage in Lower Manhattan due to Hurricane Sandy has created a gauntlet of dangerous street intersections as can be seen by this car accident at the Houston and Varick Street crossing on Friday Nov. 2, 2012. (Damon Dahlen, AOL)
Clean Drinking Water
Pedestrians fill up on water at a drinking station that had been setup at the corner of Centre and Canal Streets in Chinatown on Friday Nov. 2, 2012. The stations use water from fire hydrants and have been erected due to the blackout caused by Hurricane Sandy in Lower Manhattan. (Damon Dahlen, AOL)
Trash Picking In Chinatown
A pedestrian looks through discarded food near a supermarket located at Henry and Market Streets in Chinatown New York on Friday Nov. 2, 2012.
Fort Lee, N.J.
People wait in line for fuel at a Shell Oil station on Nov. 1, 2012 in Fort Lee, New Jersey. The US death toll from Hurricane Sandy rose to at least 85 as New York reported a major jump in fatalities caused by Monday's storm. Fuel shortages led to long lines of cars at gasoline stations in many states and the country faced a storm bill of tens of billions of dollars.
New York City
Commuters ride the F train Nov. 1, 2012 in New York City. Limited public transit has returned to New York. With the death toll continuing to rise and millions of homes and businesses without power, the U.S. east coast is attempting to recover from the effects of floods, fires and power outages brought on by Superstorm Sandy.
Toms River, N.J.
A gas station displays a "No Gas" sign on November 1, 2012 in Toms River, New Jersey. With the death toll continuing to rise and millions of homes and businesses without power, the U.S. east coast is attempting to recover from the effects of floods, fires and power outages brought on by Superstorm Sandy.
Fort Lee, N.J.
Cars wait in line for fuel at a Gulf gas station on Nov.1, 2012 in Fort Lee, New Jersey. The US death toll from Hurricane Sandy rose to at least 85 as New York reported a major jump in fatalities caused by Monday's storm. Fuel shortages led to long lines of cars at gasoline stations in many states and the country faced a storm bill of tens of billions of dollars.
Brooklyn, N.Y.
New Yorkers wait in traffic as they head into Manhattan from Brooklyn as the city continues to recover from superstorm Sandy on Nov.1, 2012, in New York, United States. Limited public transit has returned to New York and most major bridges have reopened but will require three occupants in the vehicle to pass. With the death toll currently over 70 and millions of homes and businesses without power, the US east coast is attempting to recover from the effects of floods, fires and power outages brought on by superstorm Sandy.
Hoboken, N.J.
Mud and debris liiter a street on Nov.1, 2012 in Hoboken, New Jersey. Hurricane victims continue to recover from Hurricane Sandy, which made landfall along the New Jersey shore, and left parts of the state and the surrounding area flooded and without power.
Washington, D.C.
Firefighters shoot water into a building in the 1200 block of 4th St., NE, near the recently opened Union Market, after responding to a blaze that broke out around 9pm Wednesday night.
Seaside Heights, N.J.
Debris lies on the boardwalk in front of the Casino Pier, which was partially destroyed by Superstorm Sandy on Nov.1, 2012 in Seaside Heights, New Jersey. With the death toll continuing to rise and millions of homes and businesses without power, the U.S. east coast is attempting to recover from the effects of floods, fires and power outages brought on by Superstorm Sandy.
Brooklyn Battery Tunnel, N.Y.
A New York City Police Department (NYPD) officer looks over flood waters at the entrance to the Brooklyn Battery tunnel in New York, U.S., on Nov. 1, 2012. The New York region is replacing a rail network built over a century with a patchwork constructed day-by-day to move its 8 million people again as it struggles back to life after Hurricane Sandy.
New York City
Residents charge their cell phones and computers on the East River esplanade in New York, U.S., on Nov. 1, 2012. The New York region is replacing a rail network built over a century with a patchwork constructed day-by-day to move its 8 million people again as it struggles back to life after Hurricane Sandy.
Toms River, N.J.
An American flag flies in front of a home damaged by Hurricane Sandy on Nov. 1, 2012 in Toms River, New Jersey. With the death toll continuing to rise and millions of homes and businesses without power, the U.S. east coast is attempting to recover from the effects of floods, fires and power outages brought on by superstorm Sandy.
Lower Manhattan
Water is pumped on to the street in lower Manhattan in New York, U.S., on Thursday, Nov. 1, 2012. The New York region is replacing a rail network built over a century with a patchwork constructed day-by-day to move its 8 million people again as it struggles back to life after Hurricane Sandy.
North Bergen, New Jersey
A woman leaves an Exxon gas station which was out of gas on Nov. 1, 2012 in North Bergen, New Jersey. The US death toll from Hurricane Sandy rose to at least 85 as New York reported a major jump in fatalities caused by Monday's storm. Fuel shortages led to long lines of cars at gasoline stations in many states and the country faced a storm bill of tens of billions of dollars.
Manhattan from Hoboken, N.J.
People board the NY Waterways ferry with the Manhattan skyline in the background Nov.1, 2012 in Hoboken, New Jersey. Hurricane Sandy, which made landfall along the New Jersey shore, left parts of the state and the surrounding area without power including much of lower Manhattan south of 34th Street.
South Ferry 1 Train Station, New York City
Joseph Leader, Metropolitan Tranportation Authority Vice President and Chief Maintenance Officer, shines a flashlight on standing water inside the South Ferry 1 train station in New York, N.Y., Wednesday, Oct. 31, 2012, in the wake of superstorm Sandy. The floodwaters that poured into New York's deepest subway tunnels may pose the biggest obstacle to the city's recovery from the worst natural disaster in the transit system's 108-year history.
Seaside Heights, N.J.
John Okeefe walks on the beach as a rollercoaster that once sat on the Funtown Pier in Seaside Heights, N.J., rests in the ocean on Wednesday, Oct. 31, 2012 after the pier was washed away by superstorm Sandy which made landfall Monday evening.
Grand Central Terminal, New York City
People exit a Metro-North train arriving in Grand Central Terminal during the morning rush on Nov. 1, 2012 in New York City. Some trains are back up and running into Grand Central following shutdowns in the aftermath of Superstorm Sandy. Subway train service in the city is back in a limited capacity, but with much of lower Manhattan still with out power, trains are not running there and busses are replacing them.
Brooklyn, N.Y.
Pedestrians look over a fence at a pile of boats flooded inland at the Varuna Boat Club on Oct. 31, 2012, in the Brooklyn borough of New York. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses.
Queens, N.Y.
People walk by a destroyed section of the Rockaway boardwalk in the heavily damaged Rockaway section of Queens after the historic boardwalk was washed away during Hurricane Sandy on Oct. 31, 2012 in the Queens borough of New York City. With the death toll currently at 55 and millions of homes and businesses without power, the US east coast is attempting to recover from the affects of floods, fires and power outages brought on by Hurricane Sandy. JFK airport in New York and Newark airport in New Jersey expect to resume flights on Wednesday morning and the New York Stock Exchange commenced trading after being closed for two days.
Queens, N.Y.
Damage is viewed in the Rockaway neighborhood where the historic boardwalk was washed away during Hurricane Sandy on Oct. 31, 2012 in the Queens borough of New York City. With the death toll currently at 55 and millions of homes and businesses without power, the US east coast is attempting to recover from the affects of floods, fires and power outages brought on by Hurricane Sandy. JFK airport in New York and Newark airport in New Jersey expect to resume flights on Wednesday morning and the New York Stock Exchange commenced trading after being closed for two days.
Atlantic City, N.J.
A damaged car is shown in the wake of superstorm Sandy, Wednesday, Oct. 31, 2012, in Atlantic City, N.J. Sandy was being blamed for at least six deaths across the state plus power outages that at their peak Monday affected 2.7 million residential and commercial customers.
Brooklyn, N.Y.
A worker picks up debris outside of the damaged Tatiana Grill on the Brighton Beach boardwalk, on Oct. 31, 2012, in the Brooklyn borough of New York. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses.
Source: http://www.huffingtonpost.com/2013/01/04/hurricane-sandy-aid_n_2409538.html
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Saturday, January 5, 2013
Global Desktop Platform Engineer at Systems Generators ...
Like us on Facebook: https://www.facebook.com/sysgen
Job Responsibilities
? Create and maintain a single and global desktop SOE containing all core software components and configurations
? Create and maintain a single global Citrix server baseline build
? Maintain the Firm?s mobile computing environment
? Package core and specialized applications in a consistent and modular way so that they can be published, pushed, pulled down on demand
? Create and defined hardware standards for new Firm owned desktop and laptop purchases
? Define, develop and review Citrix and Workstation standards, policies and recommendations, as needed
? Establish processes to ensure that local office feedback is incorporated into standards and policies
? Ensure duplication of effort and re-engineering is minimized
? Ensure that knowledge is captured and shared efficiently to reduce incident resolution times
? Help evaluate if it is beneficial to using Citirx technology to install specific stand alone applications to minimize costs and centralized management
? Participate and collaborate on global, regional and local projects
Job Qualifications
? Candidate must possess at least a Bachelor?s/College Degree in Engineering (Computer/Telecommunication), Computer Science/Information Technology or equivalent.
? Must have at least 4 to 6 years of professional experience building and supporting desktop/workstation and Citrix operations in a professional multi-national organization
? Has at least 3 years of working experience as L3 support With solid technical background, including exposure to GPOs, software packaging, scripting, server and virtual technologies (VMware) is also essential
? With basic knowledge and use of scripting; KIX preferred
? Basic knowledge and use of remote connectivity: VPN & SSL
? Basic knowledge and use of Document Management Systems
? Good knowledge on the Dell Optiplex and Latitude hardware platform.
? Experienced, MCSE & CCA certified preferred,
? With solid working knowledge on a wide variety of desktop hardware and Citrix XenApp server/client, including peripherals, as well as operating system, virtual computing and general business applications
? Proficiency in Microsoft Windows Desktop OS, Group Policies, and AD
? Proficiency in building, managing and maintaining an enterprise Citrix farm and interfaces.
? Knowledgeable in troubleshooting performance issues is required
? Knowledgeable in Windows Server and VMware ESX is preferred
? Advance knowledge of enterprise management systems including the Symantec Altiris Client Management Suite
? Advance knowledge on Microsoft Office.
? Good knowledge and experience managing an enterprise mobile computing environment ? IPhone and Android preferred
? With Excellent communication skills
? Candidates must be a Team player
? Must be willing to work overtime as necessary, including different shifts. On-call shift duty is mandatory
? Candidates must be willing to work in Bonifacio Taguig, Global City
? Full time/ Permanent Positions Available
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A Breast Cancer Elf? | dailyRx
(dailyRx News) Here?s an intriguing thought. What if we could reprogram cancer so it responds to treatment? That?s exactly what breast cancer experts are exploring.
Someday, doctors may be able to treat breast cancer by fiddling with something called a transcription factor. Changing the levels of one transcription factor - ELF5 - may offer new therapy options.
"Ask about your latest treatment options."
This research is coming out of Australia. Christopher J. Ormandy, PhD, of The Kinghorn Cancer Centre, Garvan Institute of Medical Research, led the study that focused on ELF5.
Most breast cancers are fed by the female hormone estrogen. These are called estrogen receptor positive (ER+) cancers. Patients with this form of the disease are treated with drugs like tamoxifen and aromatase inhibitors that block estrogen.
Transcription factors are like a light switch. They turn genes on and off. ELF5 makes breast cancer cells ignore estrogen. That means estrogen-blocking drugs don?t work anymore.
ELF5 normally works in the mammary gland during pregnancy. Its role is to make the structures needed to produce milk.
In this pre-clinical study, researchers discovered that ELF5 can actually turn an ER+ tumor cell into an estrogen receptor negative cell. The scientists also discovered in the laboratory that ELF5 may be at the heart of why some breast cancers become difficult to treat.
"This work tells us that cancers which become refractory [no longer respond] to anti-estrogen treatment often do so by elevating their levels of ELF5 and becoming functionally estrogen receptor negative," Dr. Ormandy said in a statement. ?"Our key discovery here is that by simply manipulating one transcription factor we can change the subtype of breast cancer."
Like tamoxifen, a class of drugs called aromatase inhibitors block estrogen. These drugs are: Arimidex (anastrozole), Aromasin (exemestane) and Femara (letrozole)
This research was published December 27 in?PLoS Biology.
This work was funded by The National Health and Medical Research Council of Australia, New South Wales Cancer Council, Cancer Institute New South Wales, Banque Nationale de Paris-Paribas Australia and New Zealand, RT Hall Trust, Australian Cancer Research Foundation, Prostate Cancer Foundation Australia, Cure Cancer Foundation Australia, Breast Cancer Campaign UK, and the National Breast Cancer Foundation. No conflicts of interest were disclosed.
Source: http://www.dailyrx.com/breast-cell-transcription-factor-elf5-involved-defining-breast-cancer-subtype
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Friday, January 4, 2013
Flood Insurance Funds Will Run Out Jan. 7 Without Congress OK ...
The Federal Emergency Management Agency (FEMA), which administers the National Flood Insurance Program (NFIP), has notified Congress that without the approval of additional borrowing authority, funds available to pay claims will be exhausted sometime around the week of January 7.
Payments on more than 115,000 claims in states across the country may be delayed until Congress increases the NFIP borrowing authority, according to FEMA.
Supplemental legislation currently under consideration by Congress includes $9.7 billion in additional borrowing authority to support the NFIP to address claims resulting from Superstorm Sandy and other floods. The NFIP said it continues to pay out claims related to Sandy. To date, nearly 140,000 claims have been made and $1.7 billion has been paid out to survivors.
The Senate has already passed a measure increasing the NFIP?s borrowing authority. The House has promised a vote on the NFIP monies today. The House has postponed a vote on additional disaster relief for states struck by Superstorm Sandy until Jan. 15.
?FEMA continues to work closely with Write Your Own (WYO) partner companies to meet the needs of survivors and accelerate partial payments for claims,? said Dave Miller, FEMA?s Associate Administrator for the Federal Insurance and Mitigation Administration. ?We urge timely congressional action with regard to the pending supplemental to continue to meet survivor needs.?
NFIP policies allow up to approximately 90 days after receipt of a claim to make a payment. Upon depletion of borrowing authority, FEMA said it will work to ensure any available funds, including ongoing premium payments, may be applied to claim payments
Source: http://www.claimsjournal.com/news/national/2013/01/04/220253.htm
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HANLEY WOOD ACQUIRES METROSTUDY | Metrostudy Report ...
Metrostudy to Merge with and Complement Hanley Wood?s Market Intelligence Business Resulting in More?Comprehensive Product Offerings and Services for Customers in the Housing Industry
(Washington, D.C. ? January 3, 2013) Hanley Wood LLC (?Hanley Wood?), the premier media, information and marketing services company serving the residential, commercial design and construction industries, announced today that it has acquired Metrostudy, a leading provider of primary and secondary market information to the housing and related industries nationwide.
?The acquisition of Metrostudy represents an important step in Hanley Wood?s growth strategy and demonstrates our ongoing commitment to providing customers with the information, tools and knowledge that allow them to make intelligent decisions that help grow their businesses,? said Peter Goldstone, Chief Executive Officer of Hanley Wood. ?Metrostudy?s outstanding research capabilities and broad geographic reach will greatly complement our Market Intelligence business and allow Hanley Wood to offer a product suite that will be incredibly valuable to our customers.?
Metrostudy will be combined with Hanley Wood Market Intelligence, and the merged business unit is expected to operate under the Metrostudy brand name. The complementary strengths and regional footprints of the two companies will give customers several significant advantages, including a wider geographic reach, a simplified and more intuitive user interface, and a more comprehensive platform of products, data and services. Hanley Wood Market Intelligence President, Chris Veator, will continue to lead the business, and he will work closely with Metrostudy?s executive management, Mike Castleman, Jr., Jack Inselmann and Phillip Rassel, each of whom will serve as a Senior Vice President. Metrostudy?s Chief Executive Officer, Mike Castleman, Sr., and President, Mike Inselmann, will remain with the company as senior consultants to ensure a smooth transition.
?As the housing sector continues to recover, it is increasingly important that builders and other industry participants make intelligent business and investment decisions,? said Chris Veator. ?This requires having access to the most comprehensive and reliable data with the most sophisticated analytical capabilities. The combination of these two businesses will allow us to produce even better data and analytics to help our customers best decide where to invest capital and how to best mitigate risk.?
?We are extremely excited about this transaction and the opportunities it will create for our employees and customers,? said Mike Castleman, Sr. ?Hanley Wood has an exceptional management team that recognizes the value of our platform and is committed to investing in the growth of the business. We will be able to leverage Hanley Wood?s national media properties, integrated sales platform and sophisticated analytical capabilities, and, as a result, all of our customers will greatly benefit from enhanced and additional services and functionality.?
Terms of the transaction were not disclosed.
About Hanley Wood
Hanley Wood LLC is the premier media, information and marketing services company serving the real estate construction and design industries. Through its operating platforms, the company produces award-winning digital and print publications, e-Newsletters, websites, marquee trade shows and events, Market Intelligence data and custom marketing solutions. The company also is North America?s leading publisher of home plans. http://hanleywood.com
About Metrostudy
Metrostudy is a leading provider of primary and secondary market information to the housing and related industries nationwide. Established in 1975 in Houston, Metrostudy provides research, data, analytics and consulting services that help builders, developers, lenders, suppliers, retailers, utilities and others make investment and business decisions every day. http://www.metrostudy.com
Media Contacts
RLM Finsbury
Steven Goldberg / David Millar
646.805.2000
Hanley Wood@rlmfinsbury.com
Source: http://www.metrostudyreport.com/national-housing-market/hanley-wood-acquires-metrostudy
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